Pain or No Brain?

Ages and ages ago (except it doesn’t feel that long ago – doesn’t time fly when you’re in a fibro fog!), I (with my doctor’s advice) weaned myself off Lyrica to see if we could find a better way to deal with this condition. If you followed the posts, you’ll remember that I ended up at Step 1 again and back on it…almost immediately.

Basically, it seemed, I was given the choice of being in pain (no Lyrica) or no brain (with Lyrica). I chose no pain.

I am beginning to question my choice…as my brain and everything in it quickly turns to mush.

119. fibro fogLyrica (and Neurontin, by the way) blocks the formation of new brain synapses, drastically reducing the potential for rejuvenating brain plasticity – meaning that these drugs will cause brain decline faster than any substance known to mankind! (This is not me being OTT – this is a quote by some-one else.)

Synaptic plasticity is a key feature of nerve architecture that enables your brain to tolerate stress, recover from trauma, and make changes. That’s how your brain bounces back from intense stress (or not, in our case). Hmmm….and that could be why I just can’t seem to quit smoking. Our brains, on Lyrica, are no longer flexible or “plastic.”

Doctors use them for all manner of nerve issues because they are good at suppressing symptoms. However, can we justify this use now that the actual mechanism of the drugs is finally understood? – they are creating a significant long-term reduction in nerve health.

148. fibro fogTo make matters worse (yes, they can get worse), antidepressants block the action of acetylcholine. What does acetylcholine do, you might ask? It is the primary neurotransmitter involved with memory and learning. And, how many of us take antidepressants? I know that I do. See what I mean by things getting worse?

Can it really be right to force us to make this kind of choice?





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  1. Meds are ugly BUT people in our circumstances need them so we have to accept the side effects. If we can use them for awhile and then stop them fine, but some meds we are on for the long haul.
    I never was on Lyrica, but I am on Cymbalta. Has your doctor mentioned this one? Someone on Facebook was asking if anyone on Cymbalta was having panic attacks. I don’t have panic attacks but at night I sometimes sweat profusely! I have had to get up and change my nightgown! Stress will cause me to start sweating when I am on Cymbalta.
    I have a new doctor who is very thorough and he has asked me to stop taking two meds that I have been on for a long time so I did. Yes, I had some side effects but now I have been through them and I seem to be okay.
    There might be more meds that I will be stopping.
    I should mention that now that I have stopped taking Mogadon and Flexeril I feel my head is clearer.
    I enjoy your postings and your comics. Thank you for starting this website.
    Gentle hugs

  2. Go gurrrl. It’s really important to realise that our autonomic (and every other bodily) systems are exquisite balances of control and feedback. Or, as Jon Kabat-Zinn said “there’s more right with you than wrong”. Mess with any neurotransmitter, and that balance of homeostasis is lost.
    But for fibro, there’s no fix. These meds are bad, I elaborate more on how bad Lyrica/pregabalin is at but Part 2 explains exactly who it is benefits longterm. Anything should be used as a temporary respite, in order to re-establish the rest&digest parasympathetic nervous system. And if it doesn’t work for you, NEVER double the dose. Move onto another aid, whether it’s anti-convulsant Lyrica, anti-depressants Cymbalta & Endep, or even boost dopamine with Ritalin!

  3. Actually, the reported study was only Neurontin – on rats & cultures. You can steal a look at the impact on real folk with Lyrica at

Got an opinion?